Radio-Pharmaceutical Internal Dose Assessment
by Michael G. Stabin, PhD, Richard Sparks, PhD

This course is appropriate for those who wish to gain an in-depth understanding of internal dosimetry for radiopharmaceuticals.Those completing the comprehensive on-line exam will receive a certificate of completion. To see a more in depth listing of topics, click on the links in the table of contents below.

Table of Contents:

1. Internal Dose Assessment Techniques
Introduction
Basic concepts
Main Equation
Dosimetry Systems
Marinelli/Quimby method
International Commission on Radiological Protection
The MIRD and the RADAR Systems
Practical Considerations
Problems

2. Resources for Internal Dose Assesment in Nuclear Medicine
Introduction
MIRD Resources
MIRD Books and Dose Estimate Reports
Other Resources
References
Problems

3. Kinetic Modeling
Introduction
Area Under The Curve
Exponential Curve Fitting
Regression
Compartmental Modeling
Summary
Problems

4. Standard Kinetic Models and Phantoms
Introduction
Standardized Kinetic Models
Standardized Physical Phantoms
The Need For Other Phantoms
References

5. Extrapolation of Animal Data
Animal Data Extrapolation Concepts and Methods
Experience with Animal Data Extrapolation in Internal Dosimetry
Discussion and Conclusions
Problems

6. Bone Marrow Dosimetry
Bone and marrow- overview of existing models, problem with applying to therapy, the need for more patient specific models

7. Study Design for Radiopharmaceutical Dose Assessment
FDA requirements for dose assessment in diagnosis and therapy
Study design - number of data points, types of information
Analytical methods
Optimization of therapy administrations

8. Patient Specific Dosimetry
Introduction
Approaches to Patient-Specific Dosimetry

9. Small Scale and Microdosimetry
Existing models and tools
Applicability

Copyright © 2001 by CDE, Inc. Dosimetry Services