Radiation Dose Estimates for Tl-201 Chloride (plus contaminants)

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	Estimated Radiation Dose (mGy/MBq)
ORGAN	mGy/MBq	rad/mCi
Adrenals	6.3E-02	2.3E-01
Brain	5.9E-02	2.2E-01
Breasts	3.6E-02	1.3E-01
GB Wall	8.3E-02	3.1E-01
LLI Wall	3.4E-01	1.2E+00
Small Intestine	4.5E-01	1.7E+00
Stomach	1.9E-01	6.9E-01
ULI Wall	3.3E-01	1.2E+00
Heart Wall	2.8E-01	1.0E+00
Kidneys	4.6E-01	1.7E+00
Liver	9.9E-02	3.7E-01
Lungs	4.7E-02	1.7E-01
Muscle	4.6E-02	1.7E-01
Ovaries	1.0E-01	3.7E-01
Pancreas	7.4E-02	2.7E-01
Red Marrow	5.5E-02	2.0E-01
Bone Surfaces	8.8E-02	3.3E-01
Skin	3.3E-02	1.2E-01
Spleen	1.8E-01	6.5E-01
Testes	2.0E-01	7.3E-01
Thymus	4.6E-02	1.7E-01
Thyroid	6.2E-01	2.3E+00
Urinary Bladder Wall	5.2E-02	1.9E-01
Uterus	8.5E-02	3.1E-01
Effective Dose Equivalent	1.6E-01 mSv/MBq	6.0E-01 rem/mCi

Based on data gathered in humans by Krahwinkel et al. (J Nucl Med 29(9):1582-1586, 1988) and data on testicular uptake and clearance gathered in humans by Thomas et al. (personal communication, 1994). Assumed distribution and retention:
Brain 1.76% Tb = ñ
LLI 3.6% Tb = 191 hr (Activity in wall)
Small Int 14.4% Tb = 191 hr (Activity in wall)
Stomach 2.8% Tb = 205 hr (Activity in wall)
ULI 4.7% Tb = 191 hr (Activity in wall)
Heart Wall 3.4% Tb = 179 hr
Kidneys 4.5% Tb = 260 hr 0.97% Tb = 27 hr
Liver 4.6% Tb = 218 hr
Spleen 0.74% Tb = 640 hr 0.28% Tb = 37 hr
Testes residence time 0.26 hr
Thyroid 0.29% Tb = 350 hr 0.24% Tb = 166 hr
Total Body 31% Tb = 146 hr 69% Tb = 502 hr
Urinary Bladder: 6.2% Tb = 146 hr, 13.8% Tb = 502 hr, Bladder voiding interval 4.8 hr. Contaminants assumed: Tl-200 (1%), Tl-202 (0.33%), Pb-201(0.33%), Pb-203(0.33%). Includes dose from Tl-201 Auger electrons.

Estimate calculated using phantom of Cristy & Eckerman (Report ORNL/TM-8381/V1 & V7)