Radiation Dose Estimates for Tc-99m White Blood Cells

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	Estimated Radiation Dose (mGy/MBq)
ORGAN	mGy/MBq	rad/mCi
Adrenals	1.0E-02	3.9E-02
Brain	1.4E-03	5.2E-03
Breasts	1.8E-03	6.8E-03
Gallbladder Wall	9.8E-03	3.6E-02
LLI Wall	3.5E-03	1.3E-02
Small Intestine	4.6E-03	1.7E-02
Stomach	8.7E-03	3.2E-02
ULI Wall	4.8E-03	1.8E-02
Heart Wall	5.0E-03	1.8E-02
Kidneys	1.0E-02	3.7E-02
Liver	2.7E-02	1.0E-01
Lungs	4.7E-03	1.7E-02
Muscle	2.9E-03	1.1E-02
Ovaries	3.8E-03	1.4E-02
Pancreas	1.5E-02	5.7E-02
Red Marrow	2.3E-02	8.7E-02
Bone Surfaces	1.6E-02	6.0E-02
Skin	1.4E-03	5.1E-03
Spleen	1.8E-01	6.8E-01
Testes	8.4E-04	3.1E-03
Thymus	2.3E-03	8.4E-03
Thyroid	1.5E-03	5.7E-03
Urinary Bladder Wall	1.8E-03	6.8E-03
Uterus	3.0E-03	1.1E-02
Effective Dose Equivalent	2.0E-02 mSv/MBq	7.4E-02 rem/mCi

Based on assumed model for WBC's, from data gathered in patients in several sources (ICRP 53; Goodwin et al., Third Int. Radiopharm. Dosimetry Symposium, Oak Ridge, TN, 1980, p. 88-101; Marcus et al. Nucl Med Comm 9:249-254, 1988; Thakur et al. Semin Nucl Med 14:107-117, 1984; Weiblen et al. J Lab Clin Med 94:246-255, 1979). Assumed distribution and retention:

Liver 25% Tb = ñ
Spleen 25% Tb = ñ
Marrow 40% Tb = ñ
Remainder 10% Tb = ñ

Estimate calculated using phantom of Cristy & Eckerman (Report ORNL/TM-8381/V1 & V7). Bone and marrow model of Eckerman (Aspects of dosimetry of radionuclides within the skeleton with particular emphasis on the active marrow, In Fourth International Radiopharmaceutical Dosimetry Symposium; A.T. Schlafke-Stelson and E. E. Watson eds. CONF-851113, Oak Ridge Associated Universities, Oak Ridge, TN 37831, 1986. pp 514-534.) used.