Radiation Dose Estimates for In-111 White Blood Cells

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	Estimated Radiation Dose (mGy/MBq)
ORGAN	mGy/MBq	rad/mCi
Adrenals	3.6E-01	1.3E+00
Brain	5.1E-02	1.9E-01
Breasts	6.7E-02	2.5E-01
Gallbladder Wall	3.4E-01	1.2E+00
LLI Wall	1.2E-01	4.6E-01
Small Intestine	1.6E-01	5.7E-01
Stomach	2.9E-01	1.1E+00
ULI Wall	1.6E-01	6.0E-01
Heart Wall	1.7E-01	6.2E-01
Kidneys	3.5E-01	1.3E+00
Liver	9.0E-01	3.3E+00
Lungs	1.6E-01	6.0E-01
Muscle	1.0E-01	3.9E-01
Ovaries	1.3E-01	4.8E-01
Pancreas	5.5E-01	2.0E+00
Red Marrow	6.5E-01	2.4E+00
Bone Surfaces	4.6E-01	1.7E+00
Skin	5.0E-02	1.9E-01
Spleen	5.9E+00	2.2E+01
Testes	3.0E-02	1.1E-01
Thymus	7.9E-02	2.9E-01
Thyroid	5.4E-02	2.0E-01
Urinary Bladder Wall	6.4E-02	2.4E-01
Uterus	1.0E-01	3.8E-01
Effective Dose Equivalent	6.4E-01 mSv/MBq	2.4E+00 rem/mCi

Based on assumed model for WBC's, from data gathered in patients in several sources (ICRP 53; Goodwin et al., Third Int. Radiopharm. Dosimetry Symposium, Oak Ridge, TN, 1980, p. 88-101; Marcus et al. Nucl Med Comm 9:249-254, 1988; Thakur et al. Semin Nucl Med 14:107-117, 1984; Weiblen et al. J Lab Clin Med 94:246-255, 1979). Assumed distribution and retention:

Liver 25% Tb = ñ
Spleen 25% Tb = ñ
Marrow 40% Tb = ñ
Remainder 10% Tb = ñ

Estimate calculated using phantom of Cristy & Eckerman (Report ORNL/TM-8381/V1 & V7). Bone and marrow model of Eckerman (Aspects of dosimetry of radionuclides within the skeleton with particular emphasis on the active marrow, In Fourth International Radiopharmaceutical Dosimetry Symposium; A.T. Schlafke-Stelson and E. E. Watson eds. CONF-851113, Oak Ridge Associated Universities, Oak Ridge, TN 37831, 1986. pp 514-534.) used.