Radiation Dose Estimates for Tc-99m Exametazime (HMPAO)

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	Estimated Radiation Dose
ORGAN	mGy/MBq	rad/mCi
Adrenals	5.9E-03	2.2E-02
Brain	6.9E-03	2.5E-02
Breasts	1.9E-03	7.0E-03
Gallbladder Wall	5.1E-02	1.9E-01
LLI Wall	1.5E-02	5.7E-02
Small Intestine	1.2E-02	4.6E-02
Stomach	4.2E-03	1.5E-02
ULI Wall	2.2E-02	8.0E-02
Heart Wall	3.8E-03	1.4E-02
Kidneys	3.5E-02	1.3E-01
Liver	1.5E-02	5.4E-02
Lungs	1.1E-02	4.2E-02
Muscle	2.9E-03	1.1E-02
Ovaries	7.0E-03	2.6E-02
Pancreas	5.9E-03	2.2E-02
Red Marrow	3.5E-03	1.3E-02
Bone Surfaces	4.9E-03	1.8E-02
Skin	1.5E-03	5.6E-03
Spleen	4.2E-03	1.5E-02
Testes	2.3E-03	8.4E-03
Thymus	2.4E-03	8.8E-03
Thyroid	2.7E-02	1.0E-01
Urinary Bladder Wall	2.8E-02	1.0E-01
Uterus	7.1E-03	2.6E-02
Effective Dose Equivalent	1.4E-02 mSv/MBq	5.1E-02 rem/mCi

Based on data gathered in patients (see Nucl Med Comm 11:791-799, 1990. Assumed distribution and retention:

Brain 5.1 % Tb = 92.4 hours
Gallbladder 4.0 % Tb = ñ
Kidneys 9.0 % Tb = 27.7 hours
Liver 10.4 % Tb = 116 hours 11.6 % Tb = 0.73 hours
Lungs 8.6 % Tb = 69 hours 1.4 % Tb = 1.6 hours
Thyroid 0.54 % Tb = 54.1 hours 0.26 % Tb = 1.07 hours
Remainder of
the body 29.4 % Tb = 43.3 hours 16.6 % Tb = 0.93 hours

Dynamic Bladder Model used (4.80 hour void)
24.0 % Tb = 8.30 hours
13.0 % Tb = 0.55 hours
ICRP 30 GI Model used, with 14.0 % to the small intestine

Estimate calculated using phantom of Cristy & Eckerman (Report ORNL/TM-8381/V1