Radiation Dose Estimates for I-123 mIBG

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	Estimated Radiation Dose (mGy/MBq)
ORGAN	mGy/MBq	rad/mCi
Adrenals	1.6E-02	5.9E-02
Brain	4.8E-03	1.8E-02
Breasts	5.2E-03	1.9E-02
Gallbladder Wall	2.2E-02	8.0E-02
LLI Wall	9.8E-03	3.6E-02
Small Intestine	9.3E-03	3.4E-02
Stomach	8.6E-03	3.2E-02
ULI Wall	9.9E-03	3.6E-02
Heart Wall	1.8E-02	6.7E-02
Kidneys	1.1E-02	3.9E-02
Liver	7.3E-02	2.7E-01
Lungs	9.3E-03	3.4E-02
Muscle	7.1E-03	2.6E-02
Ovaries	9.9E-03	3.7E-02
Pancreas	1.3E-02	4.9E-02
Red Marrow	7.1E-03	2.6E-02
Bone Surfaces	1.2E-02	4.3E-02
Salivary Glands	2.5E-02	9.4E-02
Skin	4.4E-03	1.6E-02
Spleen	2.1E-02	7.7E-02
Testes	6.9E-03	2.6E-02
Thymus	6.6E-03	2.5E-02
Thyroid	4.7E-03	1.7E-02
Urinary Bladder Wall	9.4E-02	3.5E-01
Uterus	1.40E-02	5.40E-02
Effective Dose Equivalent	1.9E-02 mSv/MBq	7.1E-02 rem/mCi

Based on data gathered in patients - Jacobsson et al, 4th International
Radiopharmaceutical Dosimetry Symposium, CONF-851113, pp. 389-398. Assumed distribution and retention:

Total body 63 % Tb = 32.8 hours 36 % Tb = 3.05 hours 1 % Tb = ñ
Liver 21 % Tb = 32.8 hours 15 % Tb = 3.05 hours 0.3 % Tb = ñ
Spleen 0.6 % Tb = 178 hours
Sal. glands 0.04 % Tb = 32.8 hours
Thyroid 0.005 % Tb = 168 hours
Adrenals 0.02 % Tb = 48.6 hours
Heart wall 0.8 % Tb = 120 hours
Dynamic Bladder Model used (4.80 hour void) 36 % Tb = 3.00 hours 63 % Tb = 33.6 hours
Dose to salivary glands is self-dose only, based on 77 g mass and photon absorbed fractions from MIRD Pamphlet No. 8. Salivary gland activity did not contribute to other organ doses.